Marco Sassone was born in Campi Bisenzio, a Tuscan village, in 1942. The family moved to Florence in 1954, and there he met painters Ottone Rosai and Ugo Maturo, who encouraged him to follow his interest in art. In 1959 he enrolled at the Istituto Galileo Galilei, where he studied architectural drafting for several years. In 1963 he studied with painter Silvio Loffredo, a professor of art at the Accademia in Florence, himself a pupil of the Austrian master Oskar Kokoschka. Loffredo encouraged him to develop his own style and vision.
For inspiration, Sassone studied the works of the 19th century Italian impressionists, the Macchiaioli - Giovanni Fattori, Vito D'Ancona and Silvestro Lega. He began exhibiting his first works at Lo Sprone Cultural Center in Florence.
In recent years, Marco Sassone's exhibitions have included David Findlay Jr. Fine Art, New York (2010): Shrine of Saint Francis, San Francisco (2010). At Palazzo dell'Informazione, Rome (2010). At Price Tower Art Center, Oklahoma (2012). At San Angelo Museum, Texas (2014); Orange Coast College, Costa Mesa, California (2016).His Boots and Other Works. At Bata Museum, Toronto (2016); and. At Berenson Fine Art, Toronto (2017).